Cellular functions are largely performed by proteins. Defects in the production, folding, or
removal of proteins from the cell lead to perturbations in cellular functions that can result in …

Protein S-palmitoylation is a reversible post-translational modification that regulates many
key biological processes, although the full extent and functions of protein S-palmitoylation …

Protein homeostasis (proteostasis) refers to the ability of cells to preserve the correct
balance between protein synthesis, folding and degradation. Proteostasis is essential for …

Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However,
the mechanism (s) by which mutant huntingtin (mHTT) protein contributes to the …

Inherited retinal degenerations, caused by mutations in over 100 individual genes, affect
approximately 2 million people worldwide. Many of the underlying mutations cause protein …

Mediated by chaperon proteins, protein misfolding plays a crucial role in cancer
pathogenesis. Chaperonin Containing TCP1 Subunit 3 (CCT3) is one of eight subunits …

Background To evaluate plasma chaperonin containing TCP1 complex subunit 3 (CCT3)
and IQ-motif-containing GTPase-activating protein-3 (IQGAP3) as biomarker for …

Rabies, as the oldest known infectious disease, remains a serious threat to public health
worldwide. The eukaryotic cytosolic chaperonin TRiC/CCT complex facilitates the folding of …

Axons are the narrow, up-to-meter long cellular processes of neurons that form the
biological cables wiring our nervous system. Most axons must survive for an organism's …

The eukaryotic chaperonin TRiC/CCT plays a major role in assisting the folding of many
proteins through an ATP-driven allosteric cycle. Recent structures elucidated by cryo …