A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

The description of new dopamine (DA) receptor subtypes, D1-(D1 and D5) and D2-like
(D2A, D2B, D3, D4), has given an impetus to DA research. While selective agonists and …

This Commentary compares the connections of the dopaminergic system with the striatum in
rats and primates with respect to two levels of striatal organization: a tripartite functional …

Over the last 10 years there has been important progress towards understanding how
neurotransmitters regulate dopaminergic output. Reasonable estimates can be made of the …

Nigrostriatal dopaminergic neurons play an essential role in the central regulation of motor
functions. These functions are initiated through the release of dopamine from axon terminals …

To examine the possible causal contribution of normal or accelerated aging to the
neurodegenerative process of Parkinson's disease, we measured the influence of aging on …

Abstract Clozapine [8‐chloro‐11‐(4‐methyl‐1‐piperazinyl)‐3H‐dibenzo (b, e)(1, 4)
diazepinel, or clozaril, is a member of the dibenazepine class of antipsychotic drugs. Initially …

Background: Alzheimer's disease (AD) is characterized by a number of serious and
debilitating behavioral and psychological symptoms of dementia (BPSD). The most common …

Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study
describes the development of a novel liposome-based brain-targeting drug delivery system …

Unbiased disector stereologic cell counting was applied to sections from the human
substantia nigra that were immunostained by using a monoclonal antibody against the …