Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying
degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to …

Background Multiple sclerosis (MS) is a complex chronic inflammatory and degenerative
disorder of the central nervous system. Accelerated brain volume loss, or also termed …

In multiple sclerosis (MS), gray matter (GM) atrophy progresses in a non-random manner,
possibly in regions with a high distribution of specific neurotransmitters involved in several …

Background Heterogeneous processes may contribute to cognitive impairment in multiple
sclerosis (MS). Objective To apply a longitudinal multiparametric MRI approach to identify …

Background Choroid plexus (CP) enlargement has been suggested as a reliable marker of
neuroinflammation in adult multiple sclerosis (MS). We investigated CP volume in patients …

Background: To evaluate retinal vessel density (VD) in macular and in peripapillary regions
in patients with recent onset of multiple sclerosis, at initial demyelinating event (IDE) and in …

Objectives Gay matter (GM) involvement is clinically relevant in multiple sclerosis (MS).
Using source-based morphometry (SBM), we characterized GM atrophy and its 1-year …

Objective: We investigated whether diffusion tensor imaging (DTI) could reveal early
hippocampal damage and clinically relevant correlates of memory impairment in persons …

Background Myelin loss is a central feature of several neurodegenerative diseases,
including Alzheimer's disease (AD). In animal studies, a link has been established between …

Background In multiple sclerosis (MS), knowledge about how spinal cord abnormalities
translate into clinical manifestations is incomplete. Comprehensive, multiparametric MRI …