Synthetic chemistry has traditionally relied on reactions between reactants of high chemical
potential and transformations that proceed energetically downhill to either a global or local …

RNAs are remarkably versatile molecules that can fold into intricate three-dimensional (3D)
structures to perform diverse cellular and viral functions. Despite their biological importance …

Computational RNA design tasks are often posed as inverse problems, where sequences
are designed based on adopting a single desired secondary structure without considering …

Biocatalysis plays a vital role in the operations of all living organisms, which is usually
thought to be mediated by protein enzymes. However, the pioneering discovery of self …

RNA's ability to form and interconvert between multiple secondary and tertiary structures is
critical to its functional versatility and the traditional view of RNA structures as static entities …

RNAs play critical roles in most biological processes. Although the three-dimensional (3D)
structures of RNAs primarily determine their functions, it remains challenging to …

RNAs are critical for complex cellular functions, characterized by their structural versatility
and ability to undergo conformational transitions in response to cellular cues. The elusive …

Abstract'Ribo-organisms' of the primordial RNA World would have needed ribozymes that
catalyze RNA replication. McRae, Wan, Kristoffersen et al. recently revealed how these RNA …

RNA replication is considered a crucial stage in the origins of life. However, both enzymatic
and non-enzymatic RNA replication cycles are impeded by the “strand separation …

Catalysis and specifically autocatalysis are the quintessential building blocks of life. Yet,
although autocatalytic networks are necessary, they are not sufficient for the emergence of …