MP adds a further element of complexity in the process of assessing the quality of a liver
graft. Understanding the physiology of the parameters included in the different assessment …

Acceptance of liver grafts from donations after circulatory death (DCD) largely remains a
“black box,” particularly due to the unpredictability of the agonal phase. Abdominal …

Acute and chronic liver disease is a relevant problem worldwide. Liver function plays a
crucial role in the course of liver diseases not only in estimating prognosis but also with …

There is a lack of systematic research exploring cross-species variation in liver lobular
geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap …

Background. Normothermic machine perfusion (NMP) could provide protection to organs
from donation after circulatory death (DCD) before transplantation, and its molecular …

Ex vivo normothermic machine perfusion (NMP) preserves donor organs and permits real-
time assessment of allograft health, but the most effective indicators of graft viability are …

The need for donor pool expansion in liver transplantation has increased utilization of grafts
from so-called extended-criteria donors. Machine perfusion technology can improve …

Although consensus is lacking regarding precise cut-off values during machine perfusion,
there is general consensus on the importance of evaluating both hepatocyte and …

Introduction Posthepatectomy liver failure (PHLF) remains the main reason for short-term
mortality after liver surgery. APRI+ ALBI, aspartate aminotransferase to platelet ratio (APRI) …

Purpose In an effort to reduce waitlist mortality, extended criteria donor organs, including
those from donation after circulatory death (DCD), are being used with increasing frequency …