Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for
the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Extracellular vesicles (EVs) are membrane-enclosed particles secreted by cells and
circulating in body fluids. Initially considered as a tool to dispose of unnecessary material …

Primary cilia are specialized organelles that sense changes in extracellular milieu, and their
malfunction is responsible for several disorders (ciliopathies). Increasing evidence shows …

Senescent cells exhibit several typical features, including the senescence-associated
secretory phenotype (SASP), promoting the secretion of various inflammatory proteins and …

The exponential growth in the elderly population and their associated socioeconomic
burden have recently brought aging research into the spotlight. To integrate current …

Extracellular vesicles (EVs) in the brain play a role in neuronal homeostasis by removing
intracellular material and regulating cell-to-cell communication. Given that sex and aging …

We have previously demonstrated that circulating extracellular vesicles (EVs) are essential
to the beneficial effect of young serum on the skeletal muscle regenerative cascade. Here …

Massive CD4+ T-cell depletion as well as sustained immune activation and inflammation are
hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging …

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …