Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …

Emerging evidence indicates the deubiquitinase USP22 regulates transcriptional activation
and modification of target substrates to promote pro-oncogenic phenotypes. Here, in vivo …

Abstract Zinc-Finger (ZnF) proteins represent one of the most abundant group of proteins in
the human genome. At first characterized as DNA binding proteins, it has become …

RYBP (Ring1 and YY 1 binding protein) is a multifunctional, intrinsically disordered protein
(IDP), best described as a transcriptional regulator. It exhibits a ubiquitin-binding …

Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes lifelong
infection in humans by establishing latency after primary infection. Latent infection is a …

Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …

The reversible attachment of ubiquitin governs the interaction, activity and degradation of
proteins whereby the type and target of this conjugation determine the biological response …

DNA double-strand breaks (DSBs) represent the molecular origin of ionizing-radiation
inflicted biological effects. An increase in the ionization density causes more complex …