The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Amyloid protein is well known to induce neuronal cell death, whereas only little is known
about its effect on astrocytes. We found that amyloid peptides activated caspase 3 and …

Alterations of adult neurogenesis have been reported in several Alzheimer's disease (AD)
animal models and human brains, while defects in this process at presymptomatic/early …

Background: Amyloid-β oligomers (AβO) are species mainly involved in the synaptic and
cognitive dysfunction in Alzheimer's disease. Although their action has been described …

Despite growing evidence indicating the effects of cytokines, including interleukin-1beta (IL-
1β) and tumour necrosis factor-α (TNFα), and the enzyme cyclooxygenase-2 (COX-2) in …

Normal axonal mitochondrial transport and function is essential for the maintenance of
synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within …

Introduction The proteopathic basis of AD Protein interactions in PD Induction and spread of
protein aggregates in NDDs Conclusions The misfolding and progressive aggregation of …

Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain.
It was thought previously that Aβ is only associated with Alzheimer's disease and Down …

Amyloid-beta oligomers (AβO) have been proposed as the most potent neurotoxic and
inflammation inducers in Alzheimer's disease (AD). AβO contribute to AD pathogenesis by …