Ketamine is an effective antidepressant, but there is substantial variability in patient
response and the precise mechanism of action is unclear. Neuroimaging can provide …

Major depressive disorder is a highly prevalent psychiatric disorder. Despite an extensive
range of treatment options, about a third of patients still struggle to respond to available …

Background There remain few efficacious treatments for bipolar depression, which
dominates the course of bipolar disorder (BD). Despite multiple studies reporting …

The discovery of racemic (R, S)-ketamine as a rapid-acting antidepressant and the
subsequent FDA approval of its (S)-enantiomer, esketamine, for treatment-resistant …

A large and disproportionate portion of the burden associated with major depressive
disorder (MDD) is due to treatment-resistant depression (TRD). Intravenous (R, S)-ketamine …

There is intriguing evidence suggesting that ketamine might have distinct acute and delayed
neurofunctional effects, as its acute administration transiently induces schizophrenia-like …

Objectives Pilot study validating the animal model of depression–the bilateral olfactory
bulbectomy in rats–by two nuclear magnetic resonance methods, indirectly detecting the …

Depression is one of the most common disabling mental disorders. However, first-line
treatments for depression are typically slow-acting. Ketamine, a glutamatergic modulator …