The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
[HTML][HTML] RNA methylation and cancer treatment
To this date, over 100 different types of RNA modification have been identified. Methylation
of different RNA species has emerged as a critical regulator of transcript expression. RNA …
of different RNA species has emerged as a critical regulator of transcript expression. RNA …
[HTML][HTML] m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
B Tang, Y Yang, M Kang, Y Wang, Y Wang, Y Bi, S He… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor
diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic …
diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic …
[PDF][PDF] Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm
FTO, the first RNA demethylase discovered, mediates the demethylation of internal N 6-
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from …
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from …
m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7
X Wang, R Wu, Y Liu, Y Zhao, Z Bi, Y Yao, Q Liu… - Autophagy, 2020 - Taylor & Francis
ABSTRACT N 6-methyladenosine (m6A), the most abundant internal modification on
mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism …
mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism …
[HTML][HTML] N6-methyladenosine links RNA metabolism to cancer progression
Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …
development of antibody-based sequencing technologies and the findings of m6A-related …
[HTML][HTML] FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
YTH Domain: A Family of N6-Methyladenosine (m6A) Readers
Like protein and DNA, different types of RNA molecules undergo various modifications.
Accumulating evidence suggests that these RNA modifications serve as sophisticated codes …
Accumulating evidence suggests that these RNA modifications serve as sophisticated codes …
Gene expression regulation mediated through reversible m6A RNA methylation
Cellular RNAs carry diverse chemical modifications that used to be regarded as static and
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …