Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
Learning from co-expression networks: possibilities and challenges
EAR Serin, H Nijveen, HWM Hilhorst… - Frontiers in plant …, 2016 - frontiersin.org
Plants are fascinating and complex organisms. A comprehensive understanding of the
organization, function and evolution of plant genes is essential to disentangle important …
organization, function and evolution of plant genes is essential to disentangle important …
Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration
Adult mammalian cardiomyocyte regeneration after injury is thought to be minimal.
Mononuclear diploid cardiomyocytes (MNDCMs), a relatively small subpopulation in the …
Mononuclear diploid cardiomyocytes (MNDCMs), a relatively small subpopulation in the …
ATTED-II v11: a plant gene coexpression database using a sample balancing technique by subagging of principal components
T Obayashi, H Hibara, Y Kagaya, Y Aoki… - Plant and Cell …, 2022 - academic.oup.com
Abstract ATTED-II (https://atted. jp) is a gene coexpression database for nine plant species
based on publicly available RNAseq and microarray data. One of the challenges in …
based on publicly available RNAseq and microarray data. One of the challenges in …
Aging effects on DNA methylation modules in human brain and blood tissue
Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
A comprehensive evaluation of module detection methods for gene expression data
A critical step in the analysis of large genome-wide gene expression datasets is the use of
module detection methods to group genes into co-expression modules. Because of …
module detection methods to group genes into co-expression modules. Because of …
Data based identification and prediction of nonlinear and complex dynamical systems
The problem of reconstructing nonlinear and complex dynamical systems from measured
data or time series is central to many scientific disciplines including physical, biological …
data or time series is central to many scientific disciplines including physical, biological …
Network medicine in the age of biomedical big data
Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …
Single-cell network biology for resolving cellular heterogeneity in human diseases
Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells
harboring identical genomes show a wide variety of behaviors in multicellular organisms …
harboring identical genomes show a wide variety of behaviors in multicellular organisms …
From correlation to causation: analysis of metabolomics data using systems biology approaches
Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …
down approach. Metabolomics experiments often results in discovery studies that provide …