[HTML][HTML] Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases
Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
[HTML][HTML] Alzheimer's disease as a viral disease: Revisiting the infectious hypothesis
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …
Anosmia in COVID-19: mechanisms and significance
The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a challenge for prevention due …
respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a challenge for prevention due …
Overwhelming evidence for a major role for herpes simplex virus type 1 (HSV1) in Alzheimer's disease (AD); underwhelming evidence against
RF Itzhaki - Vaccines, 2021 - mdpi.com
This review describes investigations of specific topics that lie within the general subject of
HSV1's role in AD/dementia, published in the last couple of years. They include studies on …
HSV1's role in AD/dementia, published in the last couple of years. They include studies on …
Herpes simplex virus 1 infection of neuronal and non-neuronal cells elicits specific innate immune responses and immune evasion mechanisms
Alphaherpesviruses (α-HV) are a large family of double-stranded DNA viruses which cause
many human and animal diseases. There are three human α-HVs: Herpes Simplex Viruses …
many human and animal diseases. There are three human α-HVs: Herpes Simplex Viruses …
Implications of innate immunity in post-acute sequelae of non-persistent viral infections
M Hirschenberger, V Hunszinger, KMJ Sparrer - Cells, 2021 - mdpi.com
Non-persistent viruses classically cause transient, acute infections triggering immune
responses aimed at the elimination of the pathogen. Successful viruses evolved strategies to …
responses aimed at the elimination of the pathogen. Successful viruses evolved strategies to …
[HTML][HTML] Herpes simplex virus type 1 infection leads to neurodevelopmental disorder-associated neuropathological changes
H Qiao, M Guo, J Shang, W Zhao, Z Wang, N Liu… - PLoS …, 2020 - journals.plos.org
Neonatal herpes simplex virus type 1 (HSV-1) infections contribute to various
neurodevelopmental disabilities and the subsequent long-term neurological sequelae into …
neurodevelopmental disabilities and the subsequent long-term neurological sequelae into …
The intestinal microbial metabolite nicotinamide n-oxide prevents herpes simplex encephalitis via activating mitophagy in microglia
F Li, Y Wang, X Song, Z Wang, J Jia, S Qing… - Gut …, 2022 - Taylor & Francis
Herpes simplex encephalitis (HSE), a complication of herpes simplex virus type I (HSV-1)
infection causes neurological disorder or even death in immunocompromised adults and …
infection causes neurological disorder or even death in immunocompromised adults and …
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
J Abu-Hanna, JA Patel, E Anastasakis, R Cohen… - Clinical …, 2022 - Springer
Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …
Resolution of neuroinflammation: mechanisms and potential therapeutic option
N Dokalis, M Prinz - Seminars in immunopathology, 2019 - Springer
The central nervous system (CNS) is comprised by an elaborate neural network that is under
constant surveillance by tissue-intrinsic factors for maintenance of its homeostasis. Invading …
constant surveillance by tissue-intrinsic factors for maintenance of its homeostasis. Invading …