Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of
cancer death. A complex disease arising from the interaction of environmental and host …

Esophageal squamous cell carcinoma (ESCC) is prevalent worldwide and particularly
common in certain regions of Asia. Here we report the whole-exome or targeted deep …

A growing number of studies are revealing that cells can send and receive information by
controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we …

Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic
distributions, is poorly understood at the genetic level and is in need of effective therapeutic …

Phosphodiesterases (PDE) are a diverse family of enzymes (11 isoforms so far identified)
responsible for the degradation of cyclic adenosine monophosphate (cAMP) and cyclic …

By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their …

The role of cis-elements and their aberrations remains unclear in esophageal squamous cell
carcinoma (ESCC, further abbreviated EC). Here we survey 28 H3K27ac-marked active …