Neutrophils are innate immune cells that are key to protecting the host against infection and
maintaining body homeostasis. However, if dysregulated, they can contribute to disease …

Dynamic chromatin organization instantly influences DNA accessibility through modulating
local macromolecular density and interactions, driving changes in transcription activities …

Recent advances chromatin capture, imaging techniques, and polymer modeling have
dramatically enhanced quantitative understanding of chromosomal folding. However, the …

This study demonstrates, and confirms, that chromosome territory positioning is altered in
primary senescent human dermal fibroblasts (HDFs). The chromosome territory positioning …

Chromatin–chromatin interactions and three-dimensional (3D) spatial structures are
involved in transcriptional regulation and have a decisive role in DNA replication and repair …

Recent chromatin capture, imaging techniques, and polymer modeling advancements have
dramatically enhanced our quantitative understanding of chromosomal folding. However …

Layers of genome organization are becoming increasingly better characterized, but less is
known about how these structures respond to perturbation or shape changes. Low-salt …

Cellular senescence is commonly initiated in response to replicative or cell stress pathways.
Senescent cells remain in a state of permanent cell cycle arrest, and although being …

Spatial organisation of the genome has a fundamental effect on its biological functions.
Chromatin-chromatin interactions and 3D spatial structures are involved in transcriptional …