Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (Aβ) causes …

The hypocretins (Hcrts) are two alternatively spliced neuropeptides (Hcrt1/Ox-A and
Hcrt2/Ox-B) that are synthesized exclusively in the hypothalamus. Data collected in the 20 …

Background Cognitive impairment has long challenged the patients with major depressive
disorder (MDD), hypocretins and inflammation have recently been implicated in cognitive …

The hypocretin (Hcrt)(also known as orexin) neuropeptidic wakefulness-promoting system is
implicated in the regulation of spatial memory, but its specific role and mechanisms remain …

Orexins including two peptides, orexin‐A and orexin‐B, are produced in the posterior lateral
hypothalamus. Much evidence has indicated that central orexinergic systems play numerous …

Orexin (hypocretin) is secreted from the perifornical/lateral hypothalamus and is well known
for sleep regulation. Orexin has two, orexin A and B, transcripts and two receptors, type 1 …

Aim To assess the effects of central administration of α‐pinene alone and in combination
with either bicuculline or naloxone, as GABA A and μ‐opioid receptor antagonists …

It is widely accepted that the spinal trigeminal nuclear complex, especially the subnucleus
caudalis (Vc), receives input from orofacial structures. The neuropeptides orexin-A and-B …

Background Dental pain is a main clinical problem in the elderly population and its
assessment and treatment make special challenges for health care services. However, the …

The role of hippocampus and lateral hypothalamus (LH) in modulation of formalin-induced
nociception has been established. The present study aims to examine the role of orexin …