Abstract The American Society for Metabolic and Bariatric Surgery Pediatric Committee
updated their evidence-based guidelines published in 2012, performing a comprehensive …

Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-
related injury to the hypothalamus, most commonly associated with rare, non-cancerous …

Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to …

Prader–Willi syndrome (PWS) is a genetic disorder caused by the lack of expression of
genes on the paternally inherited chromosome 15q11. 2-q13 region. The three main genetic …

Prader–Willi syndrome (PWS) is a complex multisystem disorder due to the absent
expression of the paternally active genes in the PWS critical region on chromosome 15 …

In early childhood, individuals with Prader‐Willi syndrome (PWS) experience excess weight
gain and severe hyperphagia with food compulsivity, which often leads to early onset morbid …

Severe obesity in adolescence negatively impacts upon health and wellbeing. Lifestyle
modifications do not usually achieve a sufficient degree or durability of weight loss to …

Obesity derives from impaired central control of body weight, implying interaction between
environment and an individual genetic predisposition. Genetic obesities, including …

Aims There are no treatments for the extreme hyperphagia and obesity in Prader–Willi
syndrome (PWS). The bestPWS clinical trial assessed the efficacy, safety and tolerability of …