The ubiquitin system is a major coordinator of cellular physiology through regulation of both
protein degradation and signalling pathways. A key building block of a systems-level …

Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …

Ubiquitylation is a reversible post-translational modification that has emerged as a key
regulator of most complex cellular processes. It may rival phosphorylation in scope and …

The detailed examination of enzyme molecules by mass spectrometry and other techniques
continues to identify hundreds of distinct PTMs. Recently, global analyses of enzymes using …

Ubiquitination is a reversible modification that influences a broad range of physiological
processes. There are approximately 90 deubiquitinases (DUBs) encoded in the human …

Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational
modifications. Epigenetics plays a major role in cancer development, all stable changes to …

Peroxin 5 (PEX5), the peroxisomal protein shuttling receptor, binds newly synthesized
peroxisomal matrix proteins in the cytosol and promotes their translocation across the …

The androgen receptor (AR), a member of the nuclear receptor family, is a transcription
factor involved in prostate cell growth, homeostasis, and transformation. AR is a key protein …

Ubiquitination is a specific protein degradation and reversible post-translational modification
process that can be reversed by deubiquitinase (DUBs). DUBs can hydrolyze and release …

The ubiquitin–proteasome system (UPS) regulates protein quality or control and plays
essential roles in several biological and biochemical processes in fungi. Here, we present …