Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

Tobacco use disorder continues to be a leading public health issue and cause of premature
death in the United States. Nicotine is considered as the major tobacco alkaloid causing …

Evidence so far indicates that therapies targeting a single aspect of Alzheimer's disease
(AD) have no sufficient efficacy in diminishing long-term the progression of AD …

Human mutations and haploinsufficiency of the SHANK family genes are associated with
autism spectrum disorders (ASD) and intellectual disability (ID). Complex phenotypes have …

Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess
cognitive-improving abilities and antioxidant properties in different rodent models of …

Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease, which
is currently diagnosed via clinical symptoms and nonspecific biomarkers (such as Aβ1–42, t …

Animal survival depends on cognitive abilities such as learning and memory to adapt to
environmental changes. Memory functions require an enhanced activity and connectivity of …

Tobacco consumption is far higher among a number of psychiatric and neurological
diseases, supporting the notion that some component (s) of tobacco may underlie the oft …