During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …

This scientific statement summarizes the available preclinical, epidemiological, and clinical
trial evidence that supports the contributions of prepregnancy (and interpregnancy) …

The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …

In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …

Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal
women worldwide and is characterized by reproductive, endocrine, and metabolic …

Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …

Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules
including reactive oxygen and nitrogen species, and antioxidant defenses, has been …