Immuno-positron emission tomography (immunoPET) with 89Zr-labeled antibodies has
shown great potential in cancer imaging. It can provide important information about the …

The interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown
considerably over the last decade due to its standardized production, long half-life of 78.2 h …

Zirconium-89 has an ideal half-life for use in antibody-based PET imaging; however, when
used with the chelator DFO, there is an accumulation of radioactivity in the bone, suggesting …

We report our initial investigations into the use of tetraazamacrocycles as zirconium-89
chelators. We describe the synthesis and complete characterization of several Zr …

Purpose Currently, the most commonly used chelator for labelling antibodies with 89 Zr for
immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the …

Artificial receptors able to recognise biologically relevant molecules or ions have gained
interest in the chemical community because they offer a plethora of posibilities. Molecular …

Simple Summary Chelators are small molecules that can form a complex with a metal ion by
coordinating electron rich atoms from the chelator to the electron-poor cation …

This Tutorial Review aims to provide an overview of the use of zirconium-89 complexes in
biomedical imaging. Over the past decade there have been many new papers in this field …

Zirconium-89-labeled monoclonal antibodies and other large macromolecules such as
nanoparticles hold great promise as positron emission tomography imaging agents. In …

A key part of the development of metal based Positron Emission Tomography probes is the
chelation of the radiometal. In this review the recent developments in the chelation of four …