Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …

Antimicrobial resistance is widely recognized as a grave threat to global health in the 21st
century, since the past decades have seen a dramatic increase in human-pathogenic …

Isatin has been widely used in drug discovery. The ring is part of many naturally occurring
compounds and is used to design compounds with diverse biological activities. These isatin …

Isatin compounds' intriguing biological potential has captivated chemists' interest. A
synthetic (E)-3-((3-chloro-4-fluorophenyl) imino) indolin-2-one (3CF4I) containing isatin …

In recent years, spiro compounds have attracted significant interest in medicinal chemistry
due to their numerous biological activities attributed primarily to their versatility and structural …

Abstract Isatin (indole‐2, 3‐dione) is an oxidized indole. It is widely distributed in
mammalian tissues and body fluids, where isatin concentrations vary significantly from< 0.1 …

Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively
attached to produce novel drugs. Among various heterocyclic compounds, nitrogen-based …

In this study, a series of new isatin aroylhydrazones (5a-e and 6a-e) was synthesized and
evaluated for their anticonvulsant activities. The (Z)-configuration of compounds was …

The SARS-CoV-2 coronavirus outbreak continues to spread at a rapid rate worldwide. The
main protease (Mpro) is an attractive target for anti-COVID-19 agents. Unexpected …

A series of Schiff bases 3, 5, 7 and hydrazones 9 were achieved via reaction of 5-
(morpholinosulfonyl) indol-2, 3-dione (1) with appropriate amines and/or hydrazide …