Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …

Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly …

Nonapoptotic forms of cell death can trigger sterile inflammation through the release of
damage-associated molecular patterns, which are recognized by innate immune receptors …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …