RA is characterized by a systemic inflammatory state, in which immune cells and soluble
mediators play a crucial role. These inflammatory processes resemble those in other chronic …

Adipose tissue secretes highly bioactive factors, the adipokines. Systemic levels of
adipokines are often altered in the presence of inflammation. In turn, adipokines affect …

Adipose tissue has been more accepted as an active contributor to whole body
homeostasis, rather than just a fat depot, since leptin, a 16 kDa protein, was discovered as …

Objective To investigate the association between body mass index (BMI) and radiographic
joint damage (using the Ratingen Score [RS]) in early rheumatoid arthritis (RA). Methods …

Objective Body fat is an important source of hormones and cytokines (adipokines) that not
only regulate the energy balance, but also regulate the inflammatory and immune …

The past twenty years of research on leptin has provided crucial information on the link
between metabolic state and immune system function. Adipocytes influence not only the …

Recent therapeutic advancements in understanding of molecular and cellular mechanisms
of rheumatoid arthritis (RA) have highlighted the strategies that aim to inhibit the harmful …

Adipose tissue is ubiquitously present in the human organism. It is a structural component of
many organs including the skin, the intestinal tract, and the joints. Besides its central function …

Reports suggest leptin, which was initially described as a hormone that regulates food
intake and energy balance, has an intimate relationship, and interacts with the immune …

Introduction Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease in adults
that is associated with significant joint issues and systemic inflammation. One of the signs of …