Overlapping brain circuits for homeostatic and hedonic feeding

MA Rossi, GD Stuber - Cell metabolism, 2018 - cell.com
Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …

[HTML][HTML] The impact of sugar consumption on stress driven, emotional and addictive behaviors

A Jacques, N Chaaya, K Beecher, SA Ali… - Neuroscience & …, 2019 - Elsevier
Abstract In 2016 the World Health Organization reported 39% of the world's adult population
(over 18 y) was overweight, with western countries such as Australia and the United States …

Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

LE Mickelsen, M Bolisetty, BR Chimileski, A Fujita… - Nature …, 2019 - nature.com
The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors,
including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of …

Functional circuit architecture underlying parental behaviour

J Kohl, BM Babayan, ND Rubinstein, AE Autry… - Nature, 2018 - nature.com
Parenting is essential for the survival and wellbeing of mammalian offspring. However, we
lack a circuit-level understanding of how distinct components of this behaviour are …

Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice

D Kroeger, G Absi, C Gagliardi, SS Bandaru… - Nature …, 2018 - nature.com
The preoptic area (POA) is necessary for sleep, but the fundamental POA circuits have
remained elusive. Previous studies showed that galanin (GAL)-and GABA-producing …

Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models

AC Rupp, AJ Tomlinson, AH Affinati… - The Journal of …, 2023 - Am Soc Clin Investig
The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control
energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb …

Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus

C Gao, Y Leng, J Ma, V Rooke… - Nature …, 2020 - nature.com
Unlike the sensory thalamus, studies on the functional organization of the midline and
intralaminar nuclei are scarce, and this has hindered the establishment of conceptual …

Hypothalamic control of energy expenditure and thermogenesis

LT Tran, S Park, SK Kim, JS Lee, KW Kim… - … & Molecular Medicine, 2022 - nature.com
Energy expenditure and energy intake need to be balanced to maintain proper energy
homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the …

Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

YH Lee, YB Kim, KS Kim, M Jang, HY Song… - Nature …, 2023 - nature.com
For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking
and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known …

To eat or to sleep: That is a lateral hypothalamic question

E Arrigoni, MJS Chee, PM Fuller - Neuropharmacology, 2019 - Elsevier
The lateral hypothalamus (LH) is a functionally and anatomically complex brain region that
is involved in the regulation of many behavioral and physiological processes including …