Epidermal growth factor receptor (EGFR), the receptor for members of the epidermal growth
factor family, regulates cell proliferation and signal transduction; moreover, EGFR is related …

Because dysregulation and mutations of protein kinases play causal roles in human
disease, this family of enzymes has become one of the most important drug targets over the …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …

Cancer is currently the second leading cause of death globally and is expected to be
responsible for approximately 9.6 million deaths in 2018. With an unprecedented …

Angiogenesis is the process of formation of new blood vessels from existing ones. Vessels
serve the purpose of providing oxygen, nutrients and removal of waste from the cells. The …

Tyrosine kinases are important cellular signaling proteins that have a variety of biological
activities including cell proliferation and migration. Multiple kinases are involved in …

Angiogenesis is a process of generation of de-novo blood vessels from already existing
vasculature. It has a crucial role in different physiological process including wound healing …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Inhibition of angiogenesis has been demonstrated to be an efficacious strategy in treating
several tumors. Vascular endothelial growth factor (VEGF) is the most important protein with …