Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
K Wulff, S Gatti, JG Wettstein, RG Foster - Nature Reviews …, 2010 - nature.com
Sleep and circadian rhythm disruption are frequently observed in patients with psychiatric
disorders and neurodegenerative disease. The abnormal sleep that is experienced by these …
disorders and neurodegenerative disease. The abnormal sleep that is experienced by these …
Genetic basis of chronotype in humans: insights from three landmark GWAS
DA Kalmbach, LD Schneider, J Cheung, SJ Bertrand… - Sleep, 2017 - academic.oup.com
Abstract Study Objectives: Chronotype, or diurnal preference, refers to behavioral
manifestations of the endogenous circadian system that governs preferred timing of sleep …
manifestations of the endogenous circadian system that governs preferred timing of sleep …
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
JM Lane, J Liang, I Vlasac, SG Anderson… - Nature …, 2017 - nature.com
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
Sleep: a health imperative
Chronic sleep deficiency, defined as a state of inadequate or mistimed sleep, is a growing
and underappreciated determinant of health status. Sleep deprivation contributes to a …
and underappreciated determinant of health status. Sleep deprivation contributes to a …
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
Our sleep timing preference, or chronotype, is a manifestation of our internal biological
clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical …
clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical …
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci
NA Kimbrel, AE Ashley-Koch, XJ Qin, JH Lindquist… - Molecular …, 2022 - nature.com
To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
Sleep epidemiology—a rapidly growing field
The human body has adapted to daily changes in light such that it anticipates periods of
sleep and activity. Deviations from the circadian rhythm come with functional consequences …
sleep and activity. Deviations from the circadian rhythm come with functional consequences …
A genome-wide association study of the human metabolome in a community-based cohort
Because metabolites are hypothesized to play key roles as markers and effectors of
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated
with substantial functional deficits. Here, we identify 42 loci for self-reported daytime …
with substantial functional deficits. Here, we identify 42 loci for self-reported daytime …