There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Embryonic cells grow in environments that provide a plethora of physical cues, including
mechanical forces that shape the development of the entire embryo. Despite their …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Progression through fate decisions determines cellular composition and tissue architecture,
but how that same architecture may impact cell fate is less clear. We took advantage of …

Organoids are lumen‐containing multicellular structures that recapitulate key features of the
organs, and are increasingly used in models of disease, drug testing, and regenerative …

Following implantation, the human embryo undergoes major morphogenetic transformations
that establish the future body plan. While the molecular events underpinning this process …

Human blastocysts are comprised of the first three cell lineages of the embryo:
trophectoderm, epiblast and primitive endoderm, all of which are essential for early …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Aneuploidy, the presence of an abnormal number of chromosomes, is a major cause of early
pregnancy loss in humans. Yet, the developmental consequences of specific aneuploidies …

Stem cell-based embryo models open an unprecedented avenue for modeling
embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in …