When questioned, about 10% of the parents report suspected hypersensitivity to at least one
drug in their children. However, only a few of these reactions can be confirmed as allergic …

Children differ from adults in many aspects of pharmacotherapy, including capabilities for
drug administration, medicine-related toxicity, and taste preferences. It is essential that …

Background Unlike medicines prescribed for Food and Drug Administration–approved
indications, off-label uses may lack rigorous scientific scrutiny. Despite concerns about …

Until recently, it was considered unethical or impossible to perform clinical trials of new
medicines in children. As a consequence, many medicines used for treating children are …

The aim was to compare results of studies performed in different settings worldwide and
identify common therapeutic areas to allow for focused interventions, because off-label drug …

Objectives To determine the incidence and nature of prescribing and medication
administration errors in paediatric inpatients. Design Prospective review of drug charts to …

Purpose The aim of this review is to assess the extent of the use of off-label and/or
unlicenced drugs among hospitalised children. Methods A systematic search was made in …

Aims To investigate the potential relationship between off-label drug use and increased risk
of adverse drug reactions in paediatric outpatients. Methods A prospective …

This review aims to give an updated overview of the worldwide situation of off-label and
unlicensed drug use in the paediatric field, also taking into account the safety of this kind of …

Many drugs are still prescribed off‐label to the pediatric population. Although off‐label drug
use not supported by high level of evidence is potentially harmful, a comprehensive …