The acute or chronic drug treatments for different neurodegenerative and psychiatric
disorders are challenging from several aspects. The low bioavailability and limited brain …

Status epilepticus (SE) is an acute, life-threatening medical condition that requires
immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a …

As a non-invasive route, intranasal administration offers patient comfort and compliance
which are hurdled in parenteral drug therapy. In addition, the current recognition that the …

Epileptic seizure emergencies are life-threatening conditions, which in their most severe
form, status epilepticus, have a high mortality rate if not quickly terminated. Treatment …

Intranasal administration is a promising route for brain drug delivery. However, it can be
difficult to formulate drugs that have low water solubility into high strength intranasal …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Purpose Dexmedetomidine is an α 2-adrenoceptor agonist used for perioperative and
intensive care sedation. This study develops mechanism-based population pharmacokinetic …

Antiepileptic drugs are commonly given orally for chronic treatment of epilepsy. The
treatment of epilepsy requires administration of medications for both acute and chronic …

Acute isolated seizure, repetitive or recurrent seizures, and status epilepticus are all deemed
medical emergencies. Mortality and worse neurologic outcome are directly associated with …

Diazepam rectal gel (Diastat®) is the only FDA-approved product indicated for acute
repetitive seizures. Despite its proven efficacy, most older children and adults object to this …