The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Q Li, S Mao, H Wang, X Ye - Marine Drugs, 2022 - mdpi.com
The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic
activity is one of the important inducements for bacteria to develop drug resistance. Bacteria …

Pathogen-associated gene discovery workflows for novel antivirulence therapeutic development

WYV Lau, PK Taylor, FSL Brinkman, AHY Lee - EBioMedicine, 2023 - thelancet.com
Novel therapeutics to manage bacterial infections are urgently needed as the impact and
prevalence of antimicrobial resistance (AMR) grows. Antivirulence therapeutics are an …

Antibiofilm, antiquorum sensing and antioxidant activity of secondary metabolites from seeds of Annona senegalensis, Persoon

AN Tamfu, O Ceylan, GC Fru, M Ozturk, ME Duru… - Microbial …, 2020 - Elsevier
The increasing resistance of bacteria to antibiotics has motivated the interest in potent
natural compounds capable of disrupting bacterial cell-to-cell communication. Column …

Cheminformatics Bioprospection of Sunflower Seeds' Oils against Quorum Sensing System of Pseudomonas aeruginosa

NW S'thebe, JO Aribisala, S Sabiu - Antibiotics, 2023 - mdpi.com
Clinically significant pathogens such as Pseudomonas aeruginosa evade the effects of
antibiotics using quorum sensing (QS) systems, making antimicrobial resistance (AMR) a …

Quorum quenching activity of pentacyclic triterpenoids leads to inhibition of biofilm formation by Acinetobacter baumannii

S Paul Bhattacharya, A Mitra, A Bhattacharya, A Sen - Biofouling, 2020 - Taylor & Francis
The quorum quenching (QQ) potential of three pentacyclic triterpenoids, glycyrrhetinic acid
(GRA), ursolic acid (UA) and betulinic acid (BA), representing distinct groups of compounds …

Traditional Chinese Medicine Tanreqing Inhibits Quorum Sensing Systems in Pseudomonas aeruginosa

W Yang, Q Wei, Q Tong, K Cui, G He, L Lin… - Frontiers in …, 2020 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen that can infect a wide variety of
hosts including humans, plants, and animals. The production of virulence factors is the …

Andrographolide Inhibits Biofilm and Virulence in Listeria monocytogenes as a Quorum-Sensing Inhibitor

T Yu, X Jiang, X Xu, C Jiang, R Kang, X Jiang - Molecules, 2022 - mdpi.com
Listeria monocytogenes is a major foodborne pathogen that can cause listeriosis in humans
and animals. Andrographolide is known as a natural antibiotic and exhibits good …

In Silico and In Vitro Screening of Antipathogenic Properties of Melianthus comosus (Vahl) against Pseudomonas aeruginosa

IT Baloyi, IJ Adeosun, AA Yusuf, S Cosa - Antibiotics, 2021 - mdpi.com
Bacterial quorum sensing (QS) system regulates pathogenesis, virulence, and biofilm
formation, and together they contribute to nosocomial infections. Opportunistic pathogens …

An In Vitro Coumarin-Antibiotic Combination Treatment of Pseudomonas aeruginosa Biofilms

J Zou, Y Liu, R Guo, Y Tang, Z Shi… - Natural Product …, 2021 - journals.sagepub.com
The drug resistance of Pseudomonas aeruginosa is a worldwide problem due to its great
threat to human health. A crude extract of Angelica dahurica has been proved to have …

Traditional Chinese Medicine Tanreqing Targets Both Cell Division and Virulence in Staphylococcus aureus

W Yang, K Cui, Q Tong, S Ma, Y Sun, G He… - Frontiers in Cellular …, 2022 - frontiersin.org
Staphylococcus aureus has been recognized as an important human pathogen and poses a
serious health threat worldwide. With the advent of antibiotic resistance, such as the …