The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

A Iorga, CM Cunningham, S Moazeni… - Biology of sex …, 2017 - Springer
Epidemiologic studies have previously suggested that premenopausal females have
reduced incidence of cardiovascular disease (CVD) when compared to age-matched males …

Cardiovascular disease and breast cancer: where these entities intersect: a scientific statement from the American Heart Association

LS Mehta, KE Watson, A Barac, TM Beckie, V Bittner… - Circulation, 2018 - Am Heart Assoc
Cardiovascular disease (CVD) remains the leading cause of mortality in women, yet many
people perceive breast cancer to be the number one threat to women's health. CVD and …

Carvedilol for prevention of chemotherapy-related cardiotoxicity: the CECCY trial

MS Avila, SM Ayub-Ferreira… - Journal of the American …, 2018 - jacc.org
Background: Anthracycline (ANT) chemotherapy is associated with cardiotoxicity. Prevention
with β-blockers remains controversial. Objectives: This prospective, randomized, double …

The Role of Cardioprotection in Cancer Therapy Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review

T Omland, SL Heck, G Gulati - Cardio Oncology, 2022 - jacc.org
Cardiotoxicity is a relatively frequent and potentially serious side effect of traditional and
targeted cancer therapies. Both general measures and specific pharmacologic …

Cardio-oncology-strategies for management of cancer-therapy related cardiovascular disease

M Totzeck, M Schuler, M Stuschke, G Heusch… - International Journal of …, 2019 - Elsevier
Current therapy of advanced cancers is based on several modalities including radiotherapy,
cytotoxic chemotherapy, molecularly targeted inhibitors and antibodies targeting immune …

Impact of hormonal therapies for treatment of hormone-dependent cancers (breast and prostate) on the cardiovascular system: effects and modifications: a scientific …

TM Okwuosa, A Morgans, JW Rhee… - Circulation: Genomic …, 2021 - Am Heart Assoc
Cardiovascular disease and cancer are the leading causes of death in the United States,
and hormone-dependent cancers (breast and prostate cancer) are the most common …

Aromatase inhibitors and the risk of cardiovascular outcomes in women with breast cancer: a population-based cohort study

F Khosrow-Khavar, KB Filion, N Bouganim, S Suissa… - Circulation, 2020 - Am Heart Assoc
Background: The association between aromatase inhibitors and cardiovascular outcomes
among women with breast cancer is controversial. Given the discrepant findings from …

Toxicity of extended adjuvant therapy with aromatase inhibitors in early breast cancer: a systematic review and meta-analysis

H Goldvaser, TA Barnes, B Šeruga… - JNCI: Journal of the …, 2018 - academic.oup.com
Background A number of randomized controlled trials (RCTs) have reported improvement in
breast cancer outcomes from extending treatment with aromatase inhibitors (AIs) beyond the …

All-cause and cardiovascular disease mortality among breast cancer survivors in CLUE II, a long-standing community-based cohort

C Ramin, ML Schaeffer, Z Zheng… - JNCI: Journal of the …, 2021 - academic.oup.com
Background There is growing evidence that breast cancer survivors have higher
cardiovascular disease (CVD) mortality relative to the general population. Information on …

Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review

A Matthews, S Stanway, RE Farmer, H Strongman… - bmj, 2018 - bmj.com
Objective To investigate the effect of endocrine therapies on a wide range of specific clinical
cardiovascular disease outcomes in women with a history of non-metastatic breast cancer …