The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …

Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been
known to have deleterious roles in brain injury and disease. In particular, widespread and …

Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …

Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of NMDA
receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by which MMP …

The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the
rapidly activating delayed rectifier potassium channel (I Kr), which is important for cardiac …

Matrix metalloproteinases (MMPs) have been studied in the context of cancer due to their
ability to increase cell invasion, and were initially thought to facilitate metastasis solely …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that can
be released or activated in a neuronal activity dependent manner. Although pathologically …

Long-term synaptic plasticity is shaped by the controlled reorganization of the synaptic
proteome. A key component of this process is local proteolysis performed by the family of …

Dendritic spines are are small membranous protrusions that extend from neuronal dendrites
and harbor the majority of excitatory synapses. Increasing evidence has shown that matrix …