Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

This article proposes that biologically plausible theories of behavior can be constructed by
following a method of “phylogenetic refinement,” whereby they are progressively elaborated …

Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains
circadian rhythms by synchronization to environmental cues and is involved in diverse …

'A work of exhilarating scope and relevance... What a rare and powerful experience to feel a
book in your very body'Naomi Klein'Health is not something we can attain as individuals, for …

The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …

Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

Background Blau theorized that migraine triggers are exposures that in higher amounts
would damage the brain. The recent discovery that the TRPA1 ion channel transduces …

The serotonin transporter (SERT) ensures the recapture of serotonin and is the
pharmacological target of selective serotonin reuptake inhibitor (SSRI) antidepressants. We …