PET imaging of neuroinflammation in neurological disorders

WC Kreisl, MJ Kim, JM Coughlin, ID Henter… - The Lancet …, 2020 - thelancet.com
A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Oligodendrocyte dysfunction in amyotrophic lateral sclerosis: mechanisms and therapeutic perspectives

S Raffaele, M Boccazzi, M Fumagalli - Cells, 2021 - mdpi.com
Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps the axons in
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …

Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities

P Soares, C Silva, D Chavarria, FSG Silva… - Ageing Research …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

HJ Wobst, KL Mack, DG Brown… - Medicinal research …, 2020 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …

Glial cells—The strategic targets in amyotrophic lateral sclerosis treatment

T Filipi, Z Hermanova, J Tureckova, O Vanatko… - Journal of clinical …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease, which is characterized by
the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently …

Review of oxygenation with nanobubbles: possible treatment for hypoxic COVID-19 patients

R Afshari, O Akhavan, MR Hamblin… - ACS Applied Nano …, 2021 - ACS Publications
The coronavirus disease (COVID-19) pandemic, which has spread around the world,
caused the death of many affected patients, partly because of the lack of oxygen arising from …

New insights into oxidative stress and inflammatory response in neurodegenerative diseases

E Scarian, C Viola, F Dragoni, R Di Gerlando… - International Journal of …, 2024 - mdpi.com
Oxidative stress (OS) and inflammation are two important and well-studied pathological
hallmarks of neurodegenerative diseases (NDDs). Due to elevated oxygen consumption, the …

Carbon-11: radiochemistry and target-based PET molecular imaging applications in oncology, cardiology, and neurology

NS Goud, A Bhattacharya, RK Joshi… - Journal of Medicinal …, 2021 - ACS Publications
The positron emission tomography (PET) molecular imaging technique has gained its
universal value as a remarkable tool for medical diagnosis and biomedical research …

Nanobubble technologies: Applications in therapy from molecular to cellular level

HHWB Hansen, H Cha, L Ouyang, J Zhang, B Jin… - Biotechnology …, 2023 - Elsevier
Nanobubbles are gaseous entities suspended in bulk liquids that have widespread
beneficial usage in many industries. Nanobubbles are already proving to be versatile in …

Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact

F De Marchi, I Munitic, A Amedei, JD Berry… - Neuroscience & …, 2021 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …