The complex role of Wnt ligands in type 2 diabetes mellitus and related complications
X Nie, X Wei, H Ma, L Fan… - Journal of cellular and …, 2021 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is one of the major chronic diseases, whose prevalence is
increasing dramatically worldwide and can lead to a range of serious complications. Wnt …
increasing dramatically worldwide and can lead to a range of serious complications. Wnt …
Wnt signaling: implications in endoderm development and pancreas organogenesis
K Scheibner, M Bakhti, A Bastidas-Ponce… - Current Opinion in Cell …, 2019 - Elsevier
The pancreas is derived from the foregut endoderm during embryonic development. After
gastrulation and endoderm germ layer formation complex morphogenetic events coupled …
gastrulation and endoderm germ layer formation complex morphogenetic events coupled …
Pancreatic pericytes support β-cell function in a Tcf7l2-dependent manner
L Sakhneny, E Rachi, A Epshtein, HC Guez… - Diabetes, 2018 - Am Diabetes Assoc
Polymorphism in TCF7L2, a component of the canonical Wnt signaling pathway, has a
strong association with β-cell dysfunction and type 2 diabetes through a mechanism that has …
strong association with β-cell dysfunction and type 2 diabetes through a mechanism that has …
Integrative prediction of gene expression with chromatin accessibility and conformation data
Background Enhancers play a fundamental role in orchestrating cell state and development.
Although several methods have been developed to identify enhancers, linking them to their …
Although several methods have been developed to identify enhancers, linking them to their …
A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic …
S Kina, R Kawabata-Iwakawa, S Miyamoto… - Journal of drug …, 2021 - Taylor & Francis
Well-differentiated head and neck squamous cell carcinoma (HNSCC), accounts for
approximately 10% of all HNSCCs and, while these cases are associated with good …
approximately 10% of all HNSCCs and, while these cases are associated with good …
Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark
M Fontcuberta-PiSunyer, S Cervantes, E Miquel… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Posttranscriptional modifications of histones constitute an epigenetic mechanism that is
closely linked to both gene silencing and activation events. Trimethylation of Histone3 at …
closely linked to both gene silencing and activation events. Trimethylation of Histone3 at …
Serotonin is elevated in risk-genotype carriers of TCF7L2-rs7903146
A Leiherer, A Muendlein, CH Saely, P Fraunberger… - Scientific reports, 2019 - nature.com
Abstract The transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146 is known to be
tightly associated with an elevated risk for type 2 diabetes, whereas the molecular …
tightly associated with an elevated risk for type 2 diabetes, whereas the molecular …
[PDF][PDF] Serotonin is elevated in risk-genotype carriers of TCF7L2-rs7903146
H Drexel - core.ac.uk
Results Patient characteristics and subgroup analysis. In the discovery study, we randomly
selected 154 from a total of 1660 genotyped patients including 84 subjects with the risk …
selected 154 from a total of 1660 genotyped patients including 84 subjects with the risk …
[引用][C] Cutting the Edge of β-Cells–WNT Pathway Thrives Lineage Segregation in Pancreatic Organogenesis
SJ Willmann - Biol Syst Open Access, 2016