IL-10 is an immunomodulatory cytokine that is frequently upregulated in various types of
cancer. The biological role of IL-10 in cancer is quite complex; however, the presence of IL …

Purpose: The chimeric antigen receptor (CAR) T-cell therapy has been effective for patients
with CD19+ B-cell malignancies. Most studies have investigated the second-generation …

Abstract Purpose: Interleukin-8 (IL8) is a chemokine produced by malignant cells of multiple
cancer types. It exerts various functions in shaping protumoral vascularization and …

Retinal lymphoma, the most common form of intraocular lymphoma, is a high-grade
malignancy, usually of B-cell type, and is associated with a poor prognosis because of …

Background IL–10 is an important immunosuppressive cytokine which is frequently elevated
in tumor microenvironment. Some studies have reported that overexpression of serous IL …

Cytokines are deregulated in cancers and can contribute to tumor growth. In patients with
diffuse large-cell lymphoma (DLBCL), we observed higher levels of JAK/STAT pathway …

Purpose: This study is directed at identifying the cell source (s) of immunomodulatory
cytokines in high-grade gliomas and establishing whether the analysis of associated …

The diagnosis of primary central nervous system lymphoma (PCNSL) by radiographical
examination is often difficult because of its similarity to other brain tumors. To test whether …

Acquired ibrutinib resistance due to BTKCys481 mutations occurs in B-cell malignancies,
including those with MYD88 mutations. BTKCys481 mutations are usually subclonal, and …

Diffuse large B cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin
lymphoma, exhibits pathologic heterogeneity and a dynamic immunogenic tumor …