Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease

T Athar, K Al Balushi, SA Khan - Molecular biology reports, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative old age disease that is complex,
multifactorial, unalterable, and progressive in nature. The currently approved therapy …

[HTML][HTML] Current understanding of Alzheimer's disease diagnosis and treatment

J Weller, A Budson - F1000Research, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence
continuing to grow in part because of the aging world population. This neurodegenerative …

Dementia prevention, intervention, and care

G Livingston, A Sommerlad, V Orgeta, SG Costafreda… - The lancet, 2017 - thelancet.com
Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …

Clinical neurology and epidemiology of the major neurodegenerative diseases

MG Erkkinen, MO Kim… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis

JC Crocker, I Ricci-Cabello, A Parker, JA Hirst, A Chant… - bmj, 2018 - bmj.com
Objective To investigate the impact of patient and public involvement (PPI) on rates of
enrolment and retention in clinical trials and explore how this varies with the context and …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Cognitive symptoms of Alzheimer's disease: clinical management and prevention

E Joe, JM Ringman - bmj, 2019 - bmj.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
accumulation of amyloid β in the form of extracellular plaques and by intracellular …

Alzheimer's disease: targeting the cholinergic system

TH Ferreira-Vieira, IM Guimaraes… - Current …, 2016 - ingentaconnect.com
Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Current and future treatments in Alzheimer's disease

A Atri - Seminars in neurology, 2019 - thieme-connect.com
The foundation of current Alzheimer's disease (AD) treatment involves pharmacological and
nonpharmacological management and care planning predicated on patient-centered …

[HTML][HTML] Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The …

I Abraha, JM Rimland, FM Trotta, G Dell'Aquila… - BMJ open, 2017 - bmjopen.bmj.com
Objective To provide an overview of non-pharmacological interventions for behavioural and
psychological symptoms in dementia (BPSD). Design Systematic overview of reviews. Data …