Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Recent advances to combat ESKAPE pathogens with special reference to essential oils
Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
Discovery of N-β-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB
P Mała, E Siebs, J Meiers, K Rox, A Varrot… - Journal of Medicinal …, 2022 - ACS Publications
The Gram-negative pathogen Pseudomonas aeruginosa causes severe infections mainly in
immunocompromised or cystic fibrosis patients and is able to resist antimicrobial treatments …
immunocompromised or cystic fibrosis patients and is able to resist antimicrobial treatments …
Multifunctional Photothermal Nanorods for Targeted Treatment of Drug-Resistant Bacteria-Induced Wound Healing
Y Luo, Z Gao, H Guo, K Duan, T Lan… - … Applied Materials & …, 2024 - ACS Publications
The challenge of drug-resistant bacteria-induced wound healing in clinical and public
healthcare settings is significant due to the negative impacts on surrounding tissues and …
healthcare settings is significant due to the negative impacts on surrounding tissues and …
Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms
M Ghosh, S Raghav, P Ghosh, S Maity… - FEMS Microbiology …, 2023 - academic.oup.com
Pseudomonas aeruginosa is an opportunistic human pathogen responsible for acute and
chronic, hard to treat infections. Persistence of P. aeruginosa is due to its ability to develop …
chronic, hard to treat infections. Persistence of P. aeruginosa is due to its ability to develop …
Multiepitope glycan based laser assisted fluorescent nanocomposite with dual functionality for sensing and ablation of Pseudomonas aeruginosa
Pseudomonas aeruginosa (P. aeruginosa) infection is becoming a severe health hazard
and needs early diagnosis with high specificity. However, the non-specific binding of a …
and needs early diagnosis with high specificity. However, the non-specific binding of a …
Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB
O Metelkina, J Konstantinović, A Klein, R Shafiei… - Chemical …, 2024 - pubs.rsc.org
Dual inhibitors of two key virulence factors of Pseudomonas aeruginosa, the lectin LecA and
the protease LasB, open up an opportunity in the current antimicrobial-resistance crisis. A …
the protease LasB, open up an opportunity in the current antimicrobial-resistance crisis. A …
Ball milled glyco-graphene oxide conjugates markedly disrupted Pseudomonas aeruginosa biofilms
The engineering of the surface of nanomaterials with bioactive molecules allows controlling
their biological identity thus accessing functional materials with tuned physicochemical and …
their biological identity thus accessing functional materials with tuned physicochemical and …
Discovery of potent 1, 1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties
A Bruneau, E Gillon, A Furiga, E Brachet… - European Journal of …, 2023 - Elsevier
In this work, β-thiogalactoside mimetics bearing 1, 1-diarylmethylene or benzophenone
aglycons have been prepared and assayed for their affinity towards LecA, a lectin and …
aglycons have been prepared and assayed for their affinity towards LecA, a lectin and …
Involvement of sialoglycans in SARS‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors
S Kuhaudomlarp, A Imberty - IUBMB life, 2022 - Wiley Online Library
Viral infections have been the causes of global pandemics, including the ongoing
coronavirus disease 2019, which prompted the investigation into the infection mechanisms …
coronavirus disease 2019, which prompted the investigation into the infection mechanisms …