Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Recent advances to combat ESKAPE pathogens with special reference to essential oils

SK Panda, S Buroni, SS Swain, A Bonacorsi… - Frontiers in …, 2022 - frontiersin.org
Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Discovery of N-β-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB

P Mała, E Siebs, J Meiers, K Rox, A Varrot… - Journal of Medicinal …, 2022 - ACS Publications
The Gram-negative pathogen Pseudomonas aeruginosa causes severe infections mainly in
immunocompromised or cystic fibrosis patients and is able to resist antimicrobial treatments …

Multifunctional Photothermal Nanorods for Targeted Treatment of Drug-Resistant Bacteria-Induced Wound Healing

Y Luo, Z Gao, H Guo, K Duan, T Lan… - … Applied Materials & …, 2024 - ACS Publications
The challenge of drug-resistant bacteria-induced wound healing in clinical and public
healthcare settings is significant due to the negative impacts on surrounding tissues and …

Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms

M Ghosh, S Raghav, P Ghosh, S Maity… - FEMS Microbiology …, 2023 - academic.oup.com
Pseudomonas aeruginosa is an opportunistic human pathogen responsible for acute and
chronic, hard to treat infections. Persistence of P. aeruginosa is due to its ability to develop …

Multiepitope glycan based laser assisted fluorescent nanocomposite with dual functionality for sensing and ablation of Pseudomonas aeruginosa

P Garg, N Priyadarshi, MD Ambule, G Kaur, S Kaul… - Nanoscale, 2023 - pubs.rsc.org
Pseudomonas aeruginosa (P. aeruginosa) infection is becoming a severe health hazard
and needs early diagnosis with high specificity. However, the non-specific binding of a …

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

O Metelkina, J Konstantinović, A Klein, R Shafiei… - Chemical …, 2024 - pubs.rsc.org
Dual inhibitors of two key virulence factors of Pseudomonas aeruginosa, the lectin LecA and
the protease LasB, open up an opportunity in the current antimicrobial-resistance crisis. A …

Ball milled glyco-graphene oxide conjugates markedly disrupted Pseudomonas aeruginosa biofilms

J Tricomi, M Cacaci, G Biagiotti, L Caselli, L Niccoli… - Nanoscale, 2022 - pubs.rsc.org
The engineering of the surface of nanomaterials with bioactive molecules allows controlling
their biological identity thus accessing functional materials with tuned physicochemical and …

Discovery of potent 1, 1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties

A Bruneau, E Gillon, A Furiga, E Brachet… - European Journal of …, 2023 - Elsevier
In this work, β-thiogalactoside mimetics bearing 1, 1-diarylmethylene or benzophenone
aglycons have been prepared and assayed for their affinity towards LecA, a lectin and …

Involvement of sialoglycans in SARS‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors

S Kuhaudomlarp, A Imberty - IUBMB life, 2022 - Wiley Online Library
Viral infections have been the causes of global pandemics, including the ongoing
coronavirus disease 2019, which prompted the investigation into the infection mechanisms …