Antimicrobial resistance is now considered a major global challenge; compromising medical
advancements and our ability to treat infectious disease. Increased antimicrobial resistance …

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Infectious diseases kill over 17 million people a year, among which bacterial infections stand
out. From all the bacterial infections, tuberculosis, diarrhoea, meningitis, pneumonia, sexual …

The poor solubility of itraconazole (ITZ) has limited its efficacy in the treatment of vaginal
candidiasis. Accordingly, the improvement of ITZ solubility using a solid dispersion …

Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

Electrospinning enables to design and manufacture novel drug delivery systems capable of
advancing the local antibacterial therapy. In this study, two hydrophilic drugs–metronidazole …

Poor solubility is a major challenge that can limit the oral bioavailability of many drugs,
including delamanid, a weakly basic nitro-dihydro-imidazooxazole derivative used to treat …

As the development of novel antibiotics has been at a halt for several decades, chemically
enhancing existing drugs is a very promising approach to drug development. Herein, we …

Amorphous solid dispersions containing a polymeric component often impart improved
stability against crystallization for a small molecule relative to the pure amorphous form …

The cocrystallization of the fluoroquinolones ciprofloxacin (cip), norfloxacin (nor), and
enrofloxacin (enro) with the α, ω-dicarboxylic acids glutaric acid (glu), adipic acid (adi) …