Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones
Hemostasis is a complex physiological mechanism that functions to maintain vascular
integrity under any conditions. Its primary components are blood platelets and a coagulation …
integrity under any conditions. Its primary components are blood platelets and a coagulation …
Mathematical and computational modeling of device-induced thrombosis
Given the extensive and routine use of cardiovascular devices, a major limiting factor to their
success is the thrombotic rate that occurs. This poses direct risk to the patient and requires …
success is the thrombotic rate that occurs. This poses direct risk to the patient and requires …
[HTML][HTML] A mathematical model to quantify the effects of platelet count, shear rate, and injury size on the initiation of blood coagulation under venous flow conditions
Platelets upregulate the generation of thrombin and reinforce the fibrin clot which increases
the incidence risk of venous thromboembolism (VTE). However, the role of platelets in the …
the incidence risk of venous thromboembolism (VTE). However, the role of platelets in the …
Multiphase continuum modeling of thrombosis in aneurysms and recirculation zones
Aneurysms of saccular shape are usually associated with a slow, almost stagnant blood
flow, as well as a consequent emergence of blood clots. Despite the practical importance …
flow, as well as a consequent emergence of blood clots. Despite the practical importance …
[HTML][HTML] Modern methods of mathematical modeling of blood flow using reduced order methods
SS Simakov - Computer research and modeling, 2018 - crm-en.ics.org.ru
Simakov SS Modern methods of mathematical modeling of blood flow using reduced order
methods Issue 5, 2018 Vol. 10 All issues 2024 Vol. 16 Issue 2 Issue 1 (special issue) 2023 Vol …
methods Issue 5, 2018 Vol. 10 All issues 2024 Vol. 16 Issue 2 Issue 1 (special issue) 2023 Vol …
[HTML][HTML] Patient-specific modelling of blood coagulation
Blood coagulation represents one of the most studied processes in biomedical modelling.
However, clinical applications of this modelling remain limited because of the complexity of …
However, clinical applications of this modelling remain limited because of the complexity of …
Modeling thrombus formation and growth
H Hosseinzadegan, DK Tafti - Biotechnology and …, 2017 - Wiley Online Library
The paper reviews the state‐of‐the‐art in computational modeling of thrombus formation
and growth and related phenomena including platelet margination, activation, adhesion …
and growth and related phenomena including platelet margination, activation, adhesion …
A multiscale model of platelet-fibrin thrombus growth in the flow
A Bouchnita, V Volpert - Computers & Fluids, 2019 - Elsevier
Thrombosis is a life-threatening clinical condition characterized by the obstruction of blood
flow in a vessel due to the formation of a large thrombus. The pathogenesis of thrombosis is …
flow in a vessel due to the formation of a large thrombus. The pathogenesis of thrombosis is …
Combining mathematical modeling and deep learning to make rapid and explainable predictions of the patient-specific response to anticoagulant therapy under …
Anticoagulant drugs are commonly prescribed to prevent hypercoagulable states in patients
with venous thromboembolism. The choice of the most efficient anticoagulant and the …
with venous thromboembolism. The choice of the most efficient anticoagulant and the …
Effects of hydrophobicity, tethering and size on flow-induced activation of von Willebrand factor multimers
YK Kushchenko, AV Belyaev - Journal of Theoretical Biology, 2020 - Elsevier
Von Willebrand factor (VWF) is a multimeric protein of blood plasma that mediates platelet
adhesion to injury under strong hemodynamic flows in arterias and microvasvulature. We …
adhesion to injury under strong hemodynamic flows in arterias and microvasvulature. We …