Childhood obesity is, according to the WHO, one of the most serious challenges of the 21st
century. More than 100 million children have obesity today. Already during childhood …

Aims/hypothesis The aim of this study was to use Mendelian randomisation (MR) to identify
the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta …

Background Alterations in the brain cortical structures of patients with chronic kidney
disease (CKD) have been reported; however, the cause has not been determined yet …

Abstract Purpose of Review Rates of childhood obesity have been soaring in recent
decades. The association between obesity in adulthood and excess morbidity and mortality …

A new cardiometabolic-based chronic disease (CMBCD) model is presented that provides a
basis for early and sustainable, evidence-based therapeutic targeting to promote …

Abstract Purpose of Review Adult obesity and cardiovascular diseases are closely linked.
Yet, the relationship of childhood and adolescent obesities with cardiovascular diseases in …

Importance A rapid nutritional transition has caused greater childhood obesity prevalence in
many countries, but the repertoire of effective preventive interventions remains limited …

We examined the causal direction between gut microbiota–dependent metabolite
trimethylamine N-oxide (TMAO) or its predecessors and cardiometabolic diseases, such as …

Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains
unclear whether there are similar causal effects of obesity traits on other non-communicable …

OBJECTIVE Type 2 diabetes (T2D) is increasingly diagnosed at younger ages. We
investigated the association of adolescent obesity with incident T2D at early adulthood …