Applications of single-cell sequencing in cancer research: progress and perspectives

Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Insights gained from single-cell analysis of immune cells in the tumor microenvironment

X Ren, L Zhang, Y Zhang, Z Li… - Annual review of …, 2021 - annualreviews.org
Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …

The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma

CB Steen, BA Luca, MS Esfahani, A Azizi, BJ Sworder… - Cancer cell, 2021 - cell.com
Biological heterogeneity in diffuse large B cell lymphoma (DLBCL) is partly driven by cell-of-
origin subtypes and associated genomic lesions, but also by diverse cell types and cell …

Unraveling B cell trajectories at single cell resolution

D Morgan, V Tergaonkar - Trends in immunology, 2022 - cell.com
During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …

Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes

A Zaitsev, M Chelushkin, D Dyikanov, I Cheremushkin… - Cancer Cell, 2022 - cell.com
Cellular deconvolution algorithms virtually reconstruct tissue composition by analyzing the
gene expression of complex tissues. We present the decision tree machine learning …

Untangling the web of intratumour heterogeneity

Z Li, M Seehawer, K Polyak - Nature cell biology, 2022 - nature.com
Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and
disease progression. Technological and computational advances have enabled us to …

Advances in single-cell RNA sequencing and its applications in cancer research

D Huang, N Ma, X Li, Y Gou, Y Duan, B Liu… - Journal of hematology & …, 2023 - Springer
Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling

Y Abe, M Sakata-Yanagimoto, M Fujisawa… - Nature cell …, 2022 - nature.com
The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and
endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our …

[HTML][HTML] A single-cell atlas of diffuse large B cell lymphoma

X Ye, L Wang, M Nie, Y Wang, S Dong, W Ren, G Li… - Cell Reports, 2022 - cell.com
Diffuse large B cell lymphoma (DLBCL) is one of the most common yet aggressive types of B
cell lymphoma and remains incurable in 40% of patients. Herein, we profile the …

Treatment resistance in diffuse large B-cell lymphoma

MY He, R Kridel - Leukemia, 2021 - nature.com
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous disease and represents
the most common subtype of lymphoma. Although 60–70% of all patients can be cured by …