One hundred years have passed since Felix Hoffman, working at Bayer Industries, reported
the successful synthesis of acetylsalicylic acid as the first nonsteroidal antiinflammatory drug …

Except in rare cases, the stomach can withstand exposure to highly concentrated
hydrochloric acid, refluxed bile salts, alcohol, and foodstuffs with a wide range of …

This article reviews the pathogenic mechanism of non-steroidal anti-inflammatory drug
(NSAID)-induced gastric damage, focusing on the relation between cyclooxygenase (COX) …

Nitric oxide (NO) is now recognized as an important modulator of an enormous number of
physiological processes, ranging from blood pressure regulation to neuronal transmission to …

Background & Aims: Gastrointestinal damage caused by nonsteroidal anti-inflammatory
drugs (NSAIDs) remains a significant clinical problem. Hydrogen makes an important …

The mechanisms underlying the ability of nonsteroidal anti‐inflammatory drugs (NSAIDs) to
cause ulceration in the stomach and proximal duodenum are well understood, and this …

The use of non-steroidal anti-inflammatory drugs (NSAIDs), even in the era of selective COX-
2 inhibitors, remains limited by the ability of these agents to cause gastroduodenal …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the
world. Their analgesic, anti‐inflammatory, and antipyretic actions may be beneficial; …

Gastroduodenal ulceration and bleeding are the major limitations to the use of non-steroidal
anti-inflammatory drugs (NSAIDs). The development of safer NSAIDs or of effective …

The discovery of at least 2 cyclo-oxygenase (COX) isoenzymes, referred to as COX-1 and
COX-2, has updated our knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs). This …