Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
MM Wolfe, DR Lichtenstein… - New England Journal of …, 1999 - Mass Medical Soc
One hundred years have passed since Felix Hoffman, working at Bayer Industries, reported
the successful synthesis of acetylsalicylic acid as the first nonsteroidal antiinflammatory drug …
the successful synthesis of acetylsalicylic acid as the first nonsteroidal antiinflammatory drug …
Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?
JL Wallace - Physiological reviews, 2008 - journals.physiology.org
Except in rare cases, the stomach can withstand exposure to highly concentrated
hydrochloric acid, refluxed bile salts, alcohol, and foodstuffs with a wide range of …
hydrochloric acid, refluxed bile salts, alcohol, and foodstuffs with a wide range of …
[HTML][HTML] Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility
K Takeuchi - World journal of gastroenterology: WJG, 2012 - ncbi.nlm.nih.gov
This article reviews the pathogenic mechanism of non-steroidal anti-inflammatory drug
(NSAID)-induced gastric damage, focusing on the relation between cyclooxygenase (COX) …
(NSAID)-induced gastric damage, focusing on the relation between cyclooxygenase (COX) …
Nitric oxide in mucosal defense: a little goes a long way
JL Wallace, MJS Miller - Gastroenterology, 2000 - Elsevier
Nitric oxide (NO) is now recognized as an important modulator of an enormous number of
physiological processes, ranging from blood pressure regulation to neuronal transmission to …
physiological processes, ranging from blood pressure regulation to neuronal transmission to …
Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide–releasing diclofenac derivative in the rat
JL Wallace, G Caliendo, V Santagada, G Cirino… - Gastroenterology, 2007 - Elsevier
Background & Aims: Gastrointestinal damage caused by nonsteroidal anti-inflammatory
drugs (NSAIDs) remains a significant clinical problem. Hydrogen makes an important …
drugs (NSAIDs) remains a significant clinical problem. Hydrogen makes an important …
NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies
JL Wallace - British journal of pharmacology, 2012 - Wiley Online Library
The mechanisms underlying the ability of nonsteroidal anti‐inflammatory drugs (NSAIDs) to
cause ulceration in the stomach and proximal duodenum are well understood, and this …
cause ulceration in the stomach and proximal duodenum are well understood, and this …
Pathogenesis of NSAID-induced gastroduodenal mucosal injury
JL Wallace - Best practice & research Clinical gastroenterology, 2001 - Elsevier
The use of non-steroidal anti-inflammatory drugs (NSAIDs), even in the era of selective COX-
2 inhibitors, remains limited by the ability of these agents to cause gastroduodenal …
2 inhibitors, remains limited by the ability of these agents to cause gastroduodenal …
Current perspectives in NSAID‐induced gastropathy
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the
world. Their analgesic, anti‐inflammatory, and antipyretic actions may be beneficial; …
world. Their analgesic, anti‐inflammatory, and antipyretic actions may be beneficial; …
How do NSAIDs cause ulcer disease?
JL Wallace - Best Practice & Research Clinical Gastroenterology, 2000 - Elsevier
Gastroduodenal ulceration and bleeding are the major limitations to the use of non-steroidal
anti-inflammatory drugs (NSAIDs). The development of safer NSAIDs or of effective …
anti-inflammatory drugs (NSAIDs). The development of safer NSAIDs or of effective …
Cyclo-oxygenase isoenzymes: How recent findings affect thinking about nonsteroidal anti-inflammatory drugs
JY Jouzeau, B Terlain, A Abid, E Nédélec, P Netter - Drugs, 1997 - Springer
The discovery of at least 2 cyclo-oxygenase (COX) isoenzymes, referred to as COX-1 and
COX-2, has updated our knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs). This …
COX-2, has updated our knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs). This …