[HTML][HTML] Stapled peptides inhibitors: a new window for target drug discovery

AM Ali, J Atmaj, N Van Oosterwijk, MR Groves… - Computational and …, 2019 - Elsevier
Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …

The different facets of organelle interplay—an overview of organelle interactions

M Schrader, LF Godinho, JL Costello… - Frontiers in cell and …, 2015 - frontiersin.org
Membrane-bound organelles such as mitochondria, peroxisomes, or the endoplasmic
reticulum (ER) create distinct environments to promote specific cellular tasks such as ATP …

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

A Sugiura, S Mattie, J Prudent, HM McBride - Nature, 2017 - nature.com
Peroxisomes function together with mitochondria in a number of essential biochemical
pathways, from bile acid synthesis to fatty acid oxidation. Peroxisomes grow and divide from …

SIRT 5 inhibits peroxisomal ACOX 1 to prevent oxidative damage and is downregulated in liver cancer

XF Chen, MX Tian, RQ Sun, ML Zhang, LS Zhou… - EMBO …, 2018 - embopress.org
Peroxisomes account for~ 35% of total H2O2 generation in mammalian tissues. Peroxisomal
ACOX 1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in fatty acid β‐oxidation …

Towards repurposing the yeast peroxisome for compartmentalizing heterologous metabolic pathways

WC DeLoache, ZN Russ, JE Dueber - Nature Communications, 2016 - nature.com
Compartmentalization of enzymes into organelles is a promising strategy for limiting
metabolic crosstalk and improving pathway efficiency, but improved tools and design rules …

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

J Kong, Y Ji, YG Jeon, JS Han, KH Han, JH Lee… - Nature …, 2020 - nature.com
Lipid droplets (LDs) are key subcellular organelles for regulating lipid metabolism. Although
several subcellular organelles participate in lipid metabolism, it remains elusive whether …

Molecular nanoinformatics approach assessing the biocompatibility of biogenic silver nanoparticles with channelized intrinsic steatosis and apoptosis

PK Panda, P Kumari, P Patel, SK Samal, S Mishra… - Green …, 2022 - pubs.rsc.org
The developmental rapidity of nanotechnology poses higher risks of exposure to humans
and the environment through manufactured nanomaterials. The multitude of biological …

[HTML][HTML] Crosstalk between mitochondria and peroxisomes

J Demarquoy, F Le Borgne - World journal of biological chemistry, 2015 - ncbi.nlm.nih.gov
Mitochondria and peroxisomes are small ubiquitous organelles. They both play major roles
in cell metabolism, especially in terms of fatty acid metabolism, reactive oxygen species …

Peroxisome biogenesis, membrane contact sites, and quality control

JC Farré, SS Mahalingam, M Proietto, S Subramani - EMBO reports, 2019 - embopress.org
Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …

Dynamics of peroxisome homeostasis and its role in stress response and signaling in plants

T Su, W Li, P Wang, C Ma - Frontiers in Plant Science, 2019 - frontiersin.org
Peroxisomes play vital roles in plant growth, development, and environmental stress
response. During plant development and in response to environmental stresses, the number …