Microbial l-asparaginase: purification, characterization and applications

F Muneer, MH Siddique, F Azeem, I Rasul… - Archives of …, 2020 - Springer
Abstract l-asparaginase (EC 3.5. 1.1) is an important enzyme that has been purified and
characterized for over decades to study and evaluate its anti-carcinogenic activity against …

[HTML][HTML] Fungal L-asparaginase: Strategies for production and food applications

MC da Cunha, JG dos Santos Aguilar… - Food research …, 2019 - Elsevier
L-asparaginase (L-asparagine amidohydrolase EC 3.5. 1.1) is of great importance in
pharmaceutical and food applications. This review aims to describe the production and use …

Overview of the structure, side effects, and activity assays of l-asparaginase as a therapy drug of acute lymphoblastic leukemia

N Wang, W Ji, L Wang, W Wu, W Zhang, Q Wu… - RSC medicinal …, 2022 - pubs.rsc.org
L-Asparaginase (L-ASNase is the abbreviation, L-asparagine aminohydrolase, EC 3.5. 1.1)
is an enzyme that is clinically employed as an antitumor agent for the treatment of acute …

A systematic review of the genera Geobacillus and Parageobacillus: their evolution, current taxonomic status and major applications

IN Najar, N Thakur - Microbiology, 2020 - microbiologyresearch.org
The genus Geobacillus, belonging to the phylum Firmicutes, is one of the most important
genera and comprises thermophilic bacteria. The genus Geobacillus was erected with the …

Purification and anticancer activity of glutaminase and urease free intracellular l-asparaginase from Chaetomium sp.

N Arumugam, P Thangavelu - Protein Expression and Purification, 2022 - Elsevier
Abstract l-asparaginase is a chemotherapeutic drug used in the treatment of acute
lymphoblastic leukemia, a malignant disorder in children. l-asparaginase helps in removing …

Penicillium and Talaromyces endophytes from Tillandsia catimbauensis, a bromeliad endemic in the Brazilian tropical dry forest, and their potential for l …

LF Silva, KTLS Freire, GR Araújo-Magalhães… - World Journal of …, 2018 - Springer
This study was conducted to report the richness of endophytic Penicillium and Talaromyces
species isolated from Tillandsia catimbauensis, a bromeliad endemic in the Brazilian …

[HTML][HTML] Selection of the optimal L-asparaginase II against acute lymphoblastic leukemia: an in silico approach

A Baral, R Gorkhali, A Basnet, S Koirala, HK Bhattarai - JMIRx Med, 2021 - xmed.jmir.org
Background: L-asparaginase II (asnB), a periplasmic protein commercially extracted from E
coli and Erwinia, is often used to treat acute lymphoblastic leukemia. L-asparaginase is an …

[PDF][PDF] Statistical optimization of asparaginase production by a novel isolated bacterium Brevibacillus borstelensis ML12 using Plackett–Burman design and response …

R Mukherjee, D Bera - Journal of Applied Biology & …, 2022 - pdfs.semanticscholar.org
Asparaginase is widely used in food processing and pharmaceutical industries. It is
produced by different types of microorganisms. Applications of this enzyme depend on its …

Transformation of the L-asparaginase II gene to potato hairy roots for production of recombinant protein

A Mohammadi, A Niazi, F Aram, F Hassani… - Journal of Crop Science …, 2020 - Springer
Nowadays, transgenic plants are considered as an expression system for therapeutic
recombinant proteins. One of the approaches to recombinant protein production is the …

PURIFICATION AND PARTIAL CHARACTERIZATION OF L-ASPARAGINASE ENZYME PRODUCED BY NEWLY ISOLATE BACILLUS SP.

DN Jimat, IBF Mohamed, AS Azmi… - IIUM Engineering …, 2017 - journals.iium.edu.my
A newly bacterial producing L-asparaginase was successful isolated from Sungai Klah Hot
Spring, Perak, Malaysia and identified as Bacillus sp. It was the best L-asparaginase …