Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …

Viruses exploit the host and induce drastic metabolic changes to ensure an optimal
environment for replication and the production of viral progenies. In response, the host has …

SAMHD1 is a phosphohydrolase maintaining cellular dNTP homeostasis but also acts as a
critical regulator in innate immune responses due to its antiviral activity and association with …

MicroRNA (miRNA) dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), an
often-fatal malignancy of skin-homing CD4+ T cells for which there are few effective …

The enzyme, sterile α motif and histidine‐aspartic acid domain–containing protein 1
(SAMHD1) diminishes infection of human immunodeficiency virus type 1 (HIV‐1) by …

Macrophages are susceptible to human immunodeficiency virus type 1 (HIV-1) infection
despite abundant expression of antiviral proteins. Perhaps the most important antiviral …

SAMHD1 was initially described for its ability to efficiently restrict HIV-1 replication in myeloid
cells and resting CD4+ T cells. However, a growing body of evidence suggests that …

Background: Neurodegenerative diseases (NDs) impose significant financial and healthcare
burden on populations all over the world. The prevalence and incidence of NDs have been …

MicroRNAs (miRNAs) are crucial regulators of cellular processes, including metabolism.
Attempts to use miRNAs as therapeutic agents are being explored in several areas …

Objectives: MicroRNA-155 (miR-155) is an important regulator of immune responses in
humans. However, its role in T-cell activation in hepatitis B virus (HBV) infection remains …