Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

Numerical simulations are ubiquitous in mathematics and computational science. Several
industrial and clinical applications entail modeling complex multiphysics systems that evolve …

Computational fluid dynamics (CFD) is an important tool for the simulation of the
cardiovascular function and dysfunction. Due to the complexity of the anatomy, the …

Patients with atrial fibrillation (AF) suffer from a high risk of thrombosis. Currently, the
CHA2DS2-VASc score is the most widely used tool for risk stratification in patients with AF …

Disruptions to left atrial (LA) blood flow, such as those caused by atrial fibrillation (AF), can
lead to thrombosis in the left atrial appendage (LAA) and an increased risk of systemic …

Background. Even though nuclear factor‐erythroid 2‐related factor 2 (Nrf2) signaling has
been associated with the pathogenesis of multiple heart conditions, data on roles of Nrf2 …

Stroke is a leading cause of death and disability worldwide. Atrial myopathy, including
fibrosis, is associated with an increased risk of ischaemic stroke, but the mechanisms …

Stroke, a major global health concern often rooted in cardiac dynamics, demands precise
risk evaluation for targeted intervention. Current risk models, like the CHA 2 DS 2-VASc …

Introduction Atrial fibrillation (AF) is associated with an increased risk of stroke, often caused
by thrombi that form in the left atrium (LA), and especially in the left atrial appendage (LAA) …

Background Atrial fibrillation (AF) patients are at high risk of stroke with∼ 90% clots
originating from the left atrial appendage (LAA). Clinical understanding of blood-flow based …