Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …

The diagnostic yield of exome and genome sequencing remains low (8–70%), due to
incomplete knowledge on the genes that cause disease. To improve this, we use RNA-seq …

There is an urgent need to identify effective therapies for COVID-19 given that a broadly
available and effective vaccine is likely at least one year away. Here, we identify compounds …

There is an urgent need to identify effective therapies for COVID-19. The SARS-CoV-2 host
factor protease TMPRSS2 is required for viral entry and thus an attractive target for …

Female human pluripotent stem cells (hPSCs) routinely undergo inactive X (Xi) erosion. This
progressive loss of key repressive features follows the loss of XIST expression, the long non …

Background DNA sequencing is increasingly incorporated into the routine care of cancer
patients, many of whom also carry inherited, moderate/high-penetrance variants associated …

Abstract SAC3 domain containing 1 (SAC3D1) has been reported to be involved in
numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated …

More than three decades ago, the microarray revolution brought about high-throughput data
generation capability to biology and medicine. Subsequently, the emergence of massively …

Cancer is a relatively common disease. This study investigated the hypothesis that mutation
rates are higher in genes that can influence the onset of cancer when mutated than in genes …

Jeroen van Rooij inhoud v4.indd Page 1 Sequencing from blood to brain Jeroen van Rooij
Page 2 Page 3 Sequencing from Blood to Brain Jeroen van Rooij Page 4 Lay-out & printing …