Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

The use of skin models in drug development

SH Mathes, H Ruffner, U Graf-Hausner - Advanced drug delivery reviews, 2014 - Elsevier
Three dimensional (3D) tissue models of the human skin are probably the most developed
and understood in vitro engineered constructs. The motivation to accomplish organotypic …

Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications

L Capretto, D Carugo, S Mazzitelli, C Nastruzzi… - Advanced drug delivery …, 2013 - Elsevier
In recent years, advancements in the fields of microfluidic and lab-on-a-chip technologies
have provided unique opportunities for the implementation of nanomaterial production …

Sonoporation of cells by a parallel stable cavitation microbubble array

L Meng, X Liu, Y Wang, W Zhang, W Zhou… - Advanced …, 2019 - Wiley Online Library
Sonoporation is a targeted drug delivery technique that employs cavitation microbubbles to
generate transient pores in the cell membrane, allowing foreign substances to enter cells by …

[HTML][HTML] Acoustofluidics–changing paradigm in tissue engineering, therapeutics development, and biosensing

R Rasouli, KM Villegas, M Tabrizian - Lab on a Chip, 2023 - pubs.rsc.org
For more than 70 years, acoustic waves have been used to screen, diagnose, and treat
patients in hundreds of medical devices. The biocompatible nature of acoustic waves, their …

Microfluidic and nanofluidic intracellular delivery

J Hur, AJ Chung - Advanced Science, 2021 - Wiley Online Library
Innate cell function can be artificially engineered and reprogrammed by introducing
biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the …

Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells

JN Belling, LK Heidenreich, Z Tian… - Proceedings of the …, 2020 - National Acad Sciences
Advances in gene editing are leading to new medical interventions where patients' own cells
are used for stem cell therapies and immunotherapies. One of the key limitations to …

A comprehensive review on intracellular delivery

D Morshedi Rad, M Alsadat Rad… - Advanced …, 2021 - Wiley Online Library
Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Selective ablation of cancer cells with low intensity pulsed ultrasound

DR Mittelstein, J Ye, EF Schibber… - Applied Physics …, 2020 - pubs.aip.org
Ultrasound can be focused into deep tissues with millimeter precision to perform
noninvasive ablative therapy for diseases such as cancer. In most cases, this ablation uses …

Sonoporation: Past, present, and future

J Rich, Z Tian, TJ Huang - Advanced materials technologies, 2022 - Wiley Online Library
A surge of research in intracellular delivery technologies is underway with the increased
innovations in cell‐based therapies and cell reprogramming. Particularly, physical cell …