In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …

Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Once seen as synonymous with" anti-feminism" postfeminism i now understood as the
theoretical meeting ground between feminism and anti-foundationalist movements such as …

Summary The Persian walnut (Juglans regia L.), a diploid species native to the mountainous
regions of Central Asia, is the major walnut species cultivated for nut production and is one …

Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …

Während in Deutschland immer noch eine philosophisch-akademische und häufig stark
polarisierte Rezeption Michel Foucaults dominiert, findet in angelsächsischen Ländern eine …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Background and aims: The liver represents one of the major sites of human glucuronidation.
Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to …

Background Hepatic uridine diphosphate glucuronosyltransferase (UGT) isoform 1A1
(UGT1A1) is primarily responsible for the glucuronidation of SN‐38 (7‐ethyl‐10 …