Human UDP-glucuronosyltransferases: metabolism, expression, and disease
RH Tukey, CP Strassburg - Annual review of pharmacology and …, 2000 - annualreviews.org
In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
Role of pharmacokinetics and metabolism in drug discovery and development
JH Lin, AYH Lu - Pharmacological reviews, 1997 - ASPET
Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …
the development of novel therapeutic agents. The search for new drugs can be divided …
[图书][B] Hayes' principles and methods of toxicology
AW Hayes, T Kobets - 2023 - taylorfrancis.com
Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …
informative reference for the concepts, methodologies, and assessments integral to …
[图书][B] Postfeminisms: Feminism, cultural theory and cultural forms
A Brooks - 2002 - taylorfrancis.com
Once seen as synonymous with" anti-feminism" postfeminism i now understood as the
theoretical meeting ground between feminism and anti-foundationalist movements such as …
theoretical meeting ground between feminism and anti-foundationalist movements such as …
The walnut (Juglans regia) genome sequence reveals diversity in genes coding for the biosynthesis of non‐structural polyphenols
Summary The Persian walnut (Juglans regia L.), a diploid species native to the mountainous
regions of Central Asia, is the major walnut species cultivated for nut production and is one …
regions of Central Asia, is the major walnut species cultivated for nut production and is one …
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active …
L Iyer, CD King, PF Whitington… - The Journal of …, 1998 - Am Soc Clin Investig
Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
Neoliberalismus, Staat und Selbsttechnologien. Ein kritischer Überblick über die governmentality studies
T Lemke - Politische Vierteljahresschrift, 2000 - JSTOR
Während in Deutschland immer noch eine philosophisch-akademische und häufig stark
polarisierte Rezeption Michel Foucaults dominiert, findet in angelsächsischen Ländern eine …
polarisierte Rezeption Michel Foucaults dominiert, findet in angelsächsischen Ländern eine …
Molecular mechanism of phase I and phase II drug‐metabolizing enzymes: implications for detoxification
T Iyanagi - International review of cytology, 2007 - Elsevier
Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …
Developmental aspects of human hepatic drug glucuronidation in young children and adults
CP Strassburg, A Strassburg, S Kneip, A Barut… - Gut, 2002 - gut.bmj.com
Background and aims: The liver represents one of the major sites of human glucuronidation.
Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to …
Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to …
Phenotype‐genotype correlation of in vitro SN‐38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter …
L Iyer, D Hall, S Das, MA Mortell… - Clinical …, 1999 - Wiley Online Library
Background Hepatic uridine diphosphate glucuronosyltransferase (UGT) isoform 1A1
(UGT1A1) is primarily responsible for the glucuronidation of SN‐38 (7‐ethyl‐10 …
(UGT1A1) is primarily responsible for the glucuronidation of SN‐38 (7‐ethyl‐10 …